Article
In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects.
Journal of virology - 1 Mar 1996
Lech W J, Wang G, Yang Y L, Chee Y, Dorman K, McCrae D, Lazzeroni L C, Erickson J W, Sinsheimer J S, Kaplan A H
Abstract excerpt
We have evaluated the sequence diversity of the protease human immunodeficiency virus type 1 in vivo. Our analysis of 246 protease coding domain sequences obtained from 12 subjects indicates that amino acid substitutions predicted to give rise to protease inhibitor resistance may be present in pa...
Topics
- Amino Acid Sequence
- Antiviral Agents
- Base Sequence
- DNA, Viral
- Drug Resistance, Microbial
- Genetic Variation
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Molecular Sequence Data
- Substrate Specificity
- Zidovudine