Article
Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease.
Virology - 5 Jan 2002
Goodenow Maureen M, Bloom Gregory, Rose Stephanie L, Pomeroy Steven M, O'Brien Patricia O, Perez Elena E, Sleasman John W, Dunn Ben M
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) protease activity is targeted at nine cleavage sites comprising different amino acid sequences in the viral Gag-Pol polyprotein. Amino acid polymorphisms in protease and in regions of Gag, particularly p7(NC) and the C-cleavage site between p2 and p7(NC), occur in natural variants of HIV-1 within infected patients. Studies were designed to examine the role of natural...
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