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Article

Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.

Cancer research - 1 May 2004

Li Chun-Qi, Robles Ana I, Hanigan Christin L, Hofseth Lorne J, Trudel Laura J, Harris Curtis C, Wogan Gerald N

Abstract excerpt

Loss of p53 function by inactivating mutations results in abrogation of NO*induced apoptosis in human lymphoblastoid cells. Here we report characterization of apoptotic signaling pathways activated by NO* in these cells by cDNA microarray expression and immunoblotting. A p53-mediated transcriptional response to NO* was observed in p53-wild-type TK6, but not in closely related p53-mutant WTK1, cells. Several...

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Source

Identifiers

PMID: 15126337
DOI: 10.1158/0008-5472.can-03-1880

Genes

BBC3
PMAIP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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