Article
Enhanced UV sensitivity of yeast cells induced by overexpression of Mg(2+)-dependent protein phosphatase alpha (type 2C alpha).
Mutation research - 2 Apr 1996
Kobayashi T, Yasui A, Ohnishi M, Kato S, Sasahara Y, Kusuda K, Chida N, Yanagawa Y, Hiraga A, Tamura S
Abstract excerpt
The UV sensitivity of wild-type Saccharomyces cerevisiae cells was increased 2-fold when rat Mg(2+)-dependent protein phosphatase alpha (protein phosphatase type 2C alpha) was overexpressed in the cells. The overexpression of this enzyme rendered the rad 18 mutant (defective in postreplication repair) more UV-sensitive than was observed in the wild-type cells. However, this increase in UV sensitivity disappeared...
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