Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions.

The Journal of biological chemistry - 15 Aug 2003

Karumbati Anandi S, Deshpande Rajashree A, Jilani Arshad, Vance John R, Ramotar Dindial, Wilson Thomas E

Abstract excerpt

Tpp1 is a DNA 3'-phosphatase in Saccharomyces cerevisiae that is believed to act during strand break repair. It is homologous to one domain of mammalian polynucleotide kinase/3'-phosphatase. Unlike in yeast, we found that Tpp1 could confer resistance to methylmethane sulfonate when expressed in bacteria that lack abasic endonuclease/3'-phosphodiesterase function. This species difference was due to the absence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehydes
Share to Deoxyribonuclease (Pyrimidine Dimer)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Formamidopyrimidine Glycosylase

Share to Endodeoxyribonucleases

Share to Methyl Methanesulfonate

Share to N-Glycosyl Hydrolases

Share to Oxidants

Share to Single-Strand Specific DNA and RNA Endonucleases

Source

Identifiers

PMID: 12783866
DOI: 10.1074/jbc.M304586200

Genes

RAD1
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions.PMID 12783866Read ↗

Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases.Semantic proximity Read ↗

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe.Semantic proximity Read ↗

Identification of DNA 3'-phosphatase active site residues and their differential role in DNA binding, Mg2+ coordination, and catalysis.Semantic proximity Read ↗

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.Semantic proximity Read ↗

The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae.Semantic proximity Read ↗

Evidence for abasic site sugar phosphate-mediated cytotoxicity in alkylating agent treated Saccharomyces cerevisiae.Semantic proximity Read ↗

Polynucleotide kinase/phosphatase, Pnk1, is involved in base excision repair in Schizosaccharomyces pombe.Semantic proximity Read ↗

The role of TDP1 from budding yeast in the repair of DNA damage.Semantic proximity Read ↗

Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Tdp1 protects against oxidative DNA damage in non-dividing fission yeast.Semantic proximity Read ↗

Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.