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Article

Homologous recombination partly restores the secretion defect of underglycosylated acid phosphatase in yeast.

Current genetics - 1 Sept 1997

Praetorius-Ibba M, Monnet G, Meyhack B, Kielland-Brandt M, Nilsson-Tillgren T, Hinnen A

Abstract excerpt

The majority of secreted acid phosphatase in Saccharomyces cerevisiae is encoded by the PH05 gene. The secretion level of this acid phosphatase is directly determined by its level of glycosylation. Consequently, PHO5-11-encoded acid phosphatase which lacks 11 of 12 glycosylation sites is only poorly secreted. We have isolated and characterized both UV- and EMS-induced variants, which are partly able to restore...

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PMID: 9339343
DOI: 10.1007/s002940050265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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