Article
Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations.
Human molecular genetics - 1 Apr 2002
Warren Madhuri, Smith Amanda, Partridge Natalie, Masabanda Julio, Griffin Darren, Ashworth Alan
Abstract excerpt
Carriers of mutations in the BRCA2 gene have a high risk of developing breast and other cancers. The BRCA2 gene, which is located on human chromosome 13, encodes a very large protein of only poorly understood function. To define regions of sequence conservation and highlight potentially functionally important domains, we have cloned and characterized the chicken BRCA2 gene, the first non-mammalian BRCA2 gene to...
Topics
- Amino Acid Sequence
- Animals
- Avian Proteins
- BRCA2 Protein
- Chickens
- Chromosome Mapping
- In Situ Hybridization, Fluorescence
- Molecular Sequence Data
- Mutation
- Phylogeny
- Protein Structure, Tertiary
- Sequence Alignment
- Sequence Analysis, DNA
- Sequence Analysis, Protein