Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice.

Development (Cambridge, England) - 1 Mar 1996

Mansouri A, Stoykova A, Torres M, Gruss P

Abstract excerpt

Pax7 is a member of the paired box containing gene family. Its expression pattern suggests a function in cephalic neural crest derivatives, skeletal muscle and central nervous system development. To understand the role of Pax7 during mouse embryogenesis, we used the homologous recombination technique in embryonic stem cells and generated Pax7-/- mice. Homozygous animals are born but die shortly afer weaning. They...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Developmental
Share to Genes, Lethal
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Nerve Tissue Proteins

Share to Phenotype

Share to RNA, Messenger

Source

Identifiers

PMID: 8631261
DOI: 10.1242/dev.122.3.831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice.PMID 8631261Read ↗

Pax genes and neural tube defects in the mouse.Semantic proximity Read ↗

A transgenic neuroanatomical marker identifies cranial neural crest deficiencies associated with the Pax3 mutant Splotch.Semantic proximity Read ↗

Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives.Semantic proximity Read ↗

Divergent functions of murine Pax3 and Pax7 in limb muscle development.Semantic proximity Read ↗

Mouse Otx2 functions in the formation and patterning of rostral head.Semantic proximity Read ↗

The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene.Semantic proximity Read ↗

Neurulation in the cranial region--normal and abnormal.Semantic proximity Read ↗

Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice.Semantic proximity Read ↗

Pax: gene regulators in the developing nervous system.Semantic proximity Read ↗

Hox-7 expression during murine craniofacial development.Semantic proximity Read ↗

Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon.Semantic proximity Read ↗

The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.