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Article

The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene.

Developmental biology - 15 Oct 1998

Parr B A, Avery E J, Cygan J A, McMahon A P

Abstract excerpt

The study of spontaneous mutations has aided the understanding of developmental processes. A large collection of spontaneous or "classical" mouse mutations has been accumulated over many decades. One of the mutations causes the postaxial hemimelia (px) phenotype, which consists of limb patterning defects accompanied by Müllerian duct-associated sterility in both sexes. We were intrigued that both the limb and the...

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PMID: 9769174
DOI: 10.1006/dbio.1998.9007

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