Article
Altered peptide ligands of myelin basic protein ( MBP87-99 ) conjugated to reduced mannan modulate immune responses in mice.
Immunology - 1 Dec 2009
Katsara Maria, Yuriev Elizabeth, Ramsland Paul A, Tselios Theodore, Deraos George, Lourbopoulos Athanasios, Grigoriadis Nikolaos, Matsoukas John, Apostolopoulos Vasso
Abstract excerpt
Mutations of peptides to generate altered peptide ligands, capable of switching immune responses from T helper 1 (Th1) to T helper 2 (Th2), are promising candidates for the immunotherapy of autoimmune diseases such as multiple sclerosis (MS). We synthesized two mutant peptides from myelin basic protein 87-99 (MBP(87-99)), an immunodominant peptide epitope identified in MS. Mutations of residues K(91) and P(96),...
Topics
- Animals
- Bystander Effect
- Cross Reactions
- Encephalomyelitis, Autoimmune, Experimental
- Female
- Freund's Adjuvant
- Immunization
- Immunoglobulin G
- Interferon-gamma
- Interleukin-4
- Ligands
- Mannans
- Mice