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Article

Experimental evidence that mutated-self peptides derived from mitochondrial DNA somatic mutations have the potential to trigger autoimmunity.

Human immunology - 1 Aug 2014

Chen Lina, Duvvuri Bhargavi, Grigull Jörg, Jamnik Roni, Wither Joan E, Wu Gillian E

Abstract excerpt

Autoimmune disease is a critical health concern, whose etiology remains enigmatic. We hypothesized that immune responses to somatically mutated self proteins could have a role in the development of autoimmune disease. IFN-γ secretion by T cells stimulated with mitochondrial peptides encoded by pu...

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Identifiers

PMID: 24979674
DOI: 10.1016/j.humimm.2014.06.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24979674-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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