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Article

Identification of TRIM27 as a Novel Degradation Target of Herpes Simplex Virus 1 ICP0

16 Oct 2014

Abstract excerpt

UNLABELLED: The herpes simplex virus 1 (HSV-1) immediate early protein ICP0 performs many functions during infection, including transactivation of viral gene expression, suppression of innate immune responses, and modification and eviction of histones from viral chromatin. Although these functions of ICP0 have been characterized, the detailed mechanisms underlying ICP0's complex role during infection warrant...

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PMID: 25320289
DOI: 10.1128/jvi.02635-14

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Related research

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Research trail→

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Identification of TRIM27 as a Novel Degradation Target of Herpes Simplex Virus 1 ICP0PMID 25320289Read ↗

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Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genesSemantic proximity Read ↗

The many roles of the regulatory protein ICP27 during herpes simplex virus infectionSemantic proximity Read ↗

A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7.Semantic proximity Read ↗

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0Semantic proximity Read ↗

Effect of SUMO-SIM Interaction on the ICP0-Mediated Degradation of PML Isoform II and Its Associated Proteins in Herpes Simplex Virus 1 Infection.Semantic proximity Read ↗

Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.Semantic proximity Read ↗

Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression.Semantic proximity Read ↗

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