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Article

Suppression of Apoptosis by Dominant Negative Mutants of Cyclin-dependent Protein Kinases

1 Apr 1996

Abstract excerpt

In many cell types, position in the cell cycle appears to play a role in determining susceptibility to apoptosis (programmed cell death), and expression of various cyclins and activation of cyclin-dependent kinases (CDKs) have been shown to correlate with the onset of apoptosis in a number of experimental systems. To assess the role of CDK-mediated cell cycle events in apoptosis, we have expressed CDK dominant...

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PMID: 8626584
DOI: 10.1074/jbc.271.17.10205

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