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Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death

14 May 2002

Abstract excerpt

Precancerous cells that enter S phase without appropriate growth and viability factors undergo programmed cell death, suggesting that apoptosis may help guarantee organismic integrity [Evan, G. & Littlewood, T. (1998) Science 281, 1317-1322]. However, the connection between proliferation and cell death has remained unclear. Here, we show that the positive cell cycle regulator cyclin D3 [Matsushime H., Roussel M....

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PMID: 12011445
DOI: 10.1073/pnas.072290599

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