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Article

Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosis.

Oncogene - 3 May 2001

Makino K, Yu D, Hung M C

Abstract excerpt

Paclitaxel (Taxol) is a potent and highly effective antineoplastic agent for the treatment of advanced, drug-refractory, metastatic breast cancers. Taxol not only induces tubulin polymerization, stabilizes microtubules, blocks cell cycle progression, and induces apoptosis, but it also alters gene expression. Here, we have identified that Taxol can upregulate expression of the gene encoding the cell cycle protein...

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Source

Identifiers

PMID: 11420663
DOI: 10.1038/sj.onc.1204366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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