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Article

The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.

The Journal of biological chemistry - 27 Sept 2002

Chen Alice J, Zhou Guisheng, Juan Todd, Colicos Suzanne M, Cannon John P, Cabriera-Hansen Maria, Meyer Christian F, Jurecic Roland, Copeland Neal G, Gilbert Debra J, Jenkins Nancy A, Fletcher Fred, Tan Tse-Hua, Belmont John W

Abstract excerpt

The involvement of dual specificity phosphatases (DSPs) in the mitogen-activated protein kinase (MAPK) signaling has been mostly limited to the inactivation of MAPKs by the direct dephosphorylation of the TXY motif within their activation loop. We report the cloning and characterization of a murine DSP, called JNK pathway-associated phosphatase (JKAP), which lacks the regulatory region present in most other MAP...

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Identifiers

PMID: 12138158
DOI: 10.1074/jbc.M200453200

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DSP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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