Article
The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action.
FEBS letters - 26 Sept 1994
Bott C M, Thorneycroft S G, Marshall C J
Abstract excerpt
A mammalian mutant MAP kinase, D319N ERK2, analogous to Drosophila melanogaster sevenmaker (rlsem) gain-of-function mutation was shown to have an increased sensitivity to low levels of signalling in vivo. However, the mutation does not lead to an elevated basal kinase activity and still requires...
Topics
- 3T3 Cells
- Animals
- Enzyme Activation
- Gene Expression
- Genes, fos
- Mice
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Phosphoprotein Phosphatases
- Phosphorylation
- Promoter Regions, Genetic