Article
Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Dec 1995
Santhiya S T, Abd-alla S M, Löster J, Graw J
Abstract excerpt
BACKGROUND: From previous experiments it is known that the murine dominant cataract mutants carrying the gene Cat2 have a decreased content of gamma-crystallin-specific transcripts in the juvenile lens, when the cataract is completely expressed. Moreover, the mutant locus has been mapped recently to chromosome 1, closely linked to the gamma E-crystallin gene (map distance 0.3 +/- 0.3 cM). In the present paper we...
Topics
- Alleles
- Animals
- Cataract
- Crystallins
- Embryonic and Fetal Development
- In Situ Hybridization
- Lens, Crystalline
- Mice
- Mice, Mutant Strains
- Mutation
- Phenotype
- RNA Probes
- RNA, Messenger
- Transcription, Genetic