Article
First mutation in the βA2-crystallin encoding gene is associated with small lenses and age-related cataracts.
Investigative ophthalmology & visual science - 20 Apr 2011
Puk Oliver, Ahmad Nafees, Wagner Sibylle, Hrabé de Angelis Martin, Graw Jochen
Abstract excerpt
PURPOSE: A new mouse mutant with small lenses was identified within a mutagenesis screen. The aim of the study was to determine its molecular and morphologic characterization. METHODS: The offspring of paternally N-ethyl-N-nitrosourea (ENU)-treated C57BL/6J mice were analyzed for eye-size parameters by noninvasive in vivo laser interference biometry. RESULTS: A new mutant characterized by a clear, but...
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