Article
Characterization of Cat-2t, a radiation-induced dominant cataract mutation in mice.
Investigative ophthalmology & visual science - 1 Jul 1990
Graw J, Bors W, Gopinath P M, Merkle S, Michel C, Reitmeir P, Schäffer E, Summer K H, Wulff A
Abstract excerpt
A dominant cataract mutation was detected recently among the offspring of x-ray-irradiated male mice. The mutation, which causes total lens opacity, has provisionally been designated by the gene symbol Cat-2t. In the lenses of heterozygous and homozygous Cat-2t mutants, the epithelial and fiber cells were swollen and the lens capsule was ruptured. The histologic analysis demonstrated a complete destruction of the...
Topics
- Adenosine Triphosphate
- Animals
- Body Water
- Cataract
- Crystallins
- Electrophoresis, Polyacrylamide Gel
- Glucose-6-Phosphate
- Glucosephosphates
- Glutathione
- Lens, Crystalline
- Mice