Article
Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse.
Investigative ophthalmology & visual science - 1 Jun 2001
Graw J, Löster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M
Abstract excerpt
PURPOSE: During an ethylnitrosourea (ENU) mutagenesis screen, mice were tested for the occurrence of dominant cataracts. One particular mutant was found that caused progressive opacity and was referred to as Aey2. The purpose of the study was to provide a morphologic description, to map the mutant gene, and to characterize the underlying molecular lesion. METHODS: Isolated lenses were photographed, and histologic...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cataract
- Chromosome Mapping
- Crystallins
- DNA Mutational Analysis
- Genetic Linkage
- Lens, Crystalline
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Mutant Strains