Article
CBFA2, frequently rearranged in leukemia, is not responsible for a familial leukemia syndrome.
Leukemia - 1 Dec 1997
Legare R D, Lu D, Gallagher M, Ho C, Tan X, Barker G, Shimizu K, Ohki M, Lenny N, Hiebert S, Gilliland D G
Abstract excerpt
We have identified a family with an autosomal dominant platelet disorder with a predisposition for developing myeloid malignancies and have previously demonstrated linkage of this trait to chromosome 21q22.1-22.2. The nearest flanking markers, D21S1265 and D21S167, define the familial platelet di...
Topics
- Core Binding Factor Alpha 2 Subunit
- DNA, Complementary
- DNA-Binding Proteins
- Exons
- Gene Rearrangement
- Humans
- Leukemia
- Mutation
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins
- Transcription Factors