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Article

Mutant activin-like kinase 2 in fibrodysplasia ossificans progressiva are activated via T203 by BMP type II receptors.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2015

Fujimoto Mai, Ohte Satoshi, Osawa Kenji, Miyamoto Arei, Tsukamoto Sho, Mizuta Takato, Kokabu Shoichiro, Suda Naoto, Katagiri Takenobu

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a genetic disorder characterized by progressive heterotopic ossification in soft tissues, such as the skeletal muscles. FOP has been shown to be caused by gain-of-function mutations in activin receptor-like kinase (ALK)-2, which is a type I receptor for bone morphogenetic proteins (BMPs). In the present study, we examined the molecular mechanisms that underlie the...

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Share to Activin Receptors, Type I
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25354296
DOI: 10.1210/me.2014-1301
PMCID: PMC5414771

Genes

ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutant activin-like kinase 2 in fibrodysplasia ossificans progressiva are activated via T203 by BMP type II receptors.PMID 25354296Read ↗

A unique mutation of ALK2, G356D, found in a patient with fibrodysplasia ossificans progressiva is a moderately activated BMP type I receptor.Semantic proximity Read ↗

A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.Semantic proximity Read ↗

Deregulated bone morphogenetic protein receptor signaling underlies fibrodysplasia ossificans progressiva.Semantic proximity Read ↗

ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation.Semantic proximity Read ↗

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Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish.Semantic proximity Read ↗

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans ProgressivaSemantic proximity Read ↗

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Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva.Semantic proximity Read ↗

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