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Article

Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome.

American journal of medical genetics - 28 Aug 2000

Petersen M B, Karadima G, Samaritaki M, Avramopoulos D, Vassilopoulos D, Mikkelsen M

Abstract excerpt

Several lines of evidence suggest a shared genetic susceptibility to Down syndrome (DS) and Alzheimer disease (AD). Rare forms of autosomal-dominant AD are caused by mutations in the APP and presenilin genes (PS-1 and PS-2). The presenilin proteins have been localized to the nuclear membrane, kinetochores, and centrosomes, suggesting a function in chromosome segregation. A genetic association between a...

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Source

Identifiers

PMID: 10951459
DOI: 10.1002/1096-8628(20000828)93:5<366::aid-ajmg5>3.0.co;2-g

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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