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Article

Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.

European journal of pharmacology - 30 Mar 2001

Lynch D R, Shim S S, Seifert K M, Kurapathi S, Mutel V, Gallagher M J, Guttmann R P

Abstract excerpt

We used ligand binding to ascertain whether the pharmacological actions of RO 25-6981 [(R:(*), S:(*))-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol] match those of other NR2B (epsilon2) subunit specific agents. RO 25-6981 inhibited binding of 125I-MK801 [iodo-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohept-5,10-imine maleate] to receptors made from NR1a/epsilon2 but not...

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PMID: 11290368
DOI: 10.1016/s0014-2999(01)00868-8

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