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Article

Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds.

Development (Cambridge, England) - 1 Apr 1996

Patel K, Nittenberg R, D'Souza D, Irving C, Burt D, Wilkinson D G, Tickle C

Abstract excerpt

The Eph-related receptor tyrosine kinase gene, Cek-8, is expressed in mesenchyme at the tip of chick limb buds, with high levels of transcripts posteriorly and apically but fading out anteriorly. Expression of Cek-8 in distal mesenchyme is regulated by apical ridge- and FGF-polarising signals and retinoic acid, and is uniform across the anteroposterior axis in talpid3 mutants. These data indicate that Cek-8...

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Identifiers

PMID: 8620841
DOI: 10.1242/dev.122.4.1147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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