Article
A Cdc2 dependent checkpoint maintains diploidy in Drosophila.
Development (Cambridge, England) - 1 Apr 1996
Hayashi S
Abstract excerpt
DNA replication in G2 does not normally occur due to the checkpoint control. To elucidate its mechanism, the functions of the escargot and Dmcdc2 genes of Drosophila were studied. When escargot function was eliminated, diploid imaginal cells that were arrested in G2 lost Cyclin A, a regulatory su...
Topics
- Animals
- CDC2 Protein Kinase
- Cell Cycle
- Cell Cycle Proteins
- Cyclins
- DNA Replication
- Diploidy
- Drosophila Proteins
- Drosophila melanogaster
- G2 Phase
- Gene Expression
- Genes, Insect
- Heat-Shock Response
- Larva
- Mitosis
- Mutation
- Phosphoprotein Phosphatases
- Protein Tyrosine Phosphatases