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Article

A Cdc2 dependent checkpoint maintains diploidy in Drosophila.

Development (Cambridge, England) - 1 Apr 1996

Hayashi S

Abstract excerpt

DNA replication in G2 does not normally occur due to the checkpoint control. To elucidate its mechanism, the functions of the escargot and Dmcdc2 genes of Drosophila were studied. When escargot function was eliminated, diploid imaginal cells that were arrested in G2 lost Cyclin A, a regulatory subunit of G2/M cdk, and entered an endocycle. escargot genetically interacted with Dmcdc2 which encodes a catalytic...

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Identifiers

PMID: 8620832
DOI: 10.1242/dev.122.4.1051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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