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Article

Promiscuity rules? The dispensability of cyclin E and Cdk2.

Science's STKE : signal transduction knowledge environment - 9 Mar 2004

Su Tin Tin, Stumpff Jason

Abstract excerpt

The canonical view of the mammalian cell cycle arose from studies of cultured cells rather than mutant organisms. It depicts the many complexes of cyclin and Cdk (cyclin/Cdk) as fulfilling unique and essential steps that dictate the sequential order of cell cycle events. Recent analyses of knockout mice challenge this view. Cdk2 and cyclin E, long thought to be essential, are largely dispensable. Here, we discuss...

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Identifiers

PMID: 15026579
DOI: 10.1126/stke.2242004pe11
PMCID: PMC3242733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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