Article
Analysis of the coding genome of diffuse large B-cell lymphoma.
Nature genetics - 31 Jul 2011
Pasqualucci Laura, Trifonov Vladimir, Fabbri Giulia, Ma Jing, Rossi Davide, Chiarenza Annalisa, Wells Victoria A, Grunn Adina, Messina Monica, Elliot Oliver, Chan Joseph, Bhagat Govind, Chadburn Amy, Gaidano Gianluca, Mullighan Charles G, Rabadan Raul, Dalla-Favera Riccardo
Abstract excerpt
Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. Although a number of structural alterations have been associated with the pathogenesis of this malignancy, the full spectrum of genetic lesions that are present in the DLBCL genome, and therefore the identity of dysregulated cellular pathways, remains unknown. By combining next-generation sequencing and copy number analysis, we show...
Topics
- Chromatin
- DNA Mutational Analysis
- Diploidy
- Gene Dosage
- Gene Expression Regulation, Leukemic
- Genome, Human
- Germinal Center
- Humans
- Lymphoma, Large B-Cell, Diffuse