Article
Adaptive mutation by deletions in small mononucleotide repeats.
Science (New York, N.Y.) - 15 Jul 1994
Rosenberg S M, Longerich S, Gee P, Harris R S
Abstract excerpt
Adaptive reversion of a +1 frameshift mutation in Escherichia coli, which requires homologous recombination functions, is shown here to occur by -1 deletions in regions of small mononucleotide repeats. This pattern makes improbable recombinational mechanisms for adaptive mutation in which blocks of sequences are transferred into the mutating gene, and it supports mechanisms that use DNA polymerase errors. The...
Topics
- Base Sequence
- DNA Repair
- Escherichia coli
- Exodeoxyribonuclease V
- Exodeoxyribonucleases
- Frameshift Mutation
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Recombination, Genetic
- Repetitive Sequences, Nucleic Acid