Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele.

doi:10.1016/S1474-4422(10)70306-9

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Article

Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele.

The Lancet. Neurology - 1 Mar 2011

van der Flier Wiesje M, Pijnenburg Yolande Al, Fox Nick C, Scheltens Philip

Abstract excerpt

Some patients with early-onset Alzheimer's disease (AD) present with a distinct phenotype. Typically, the first and most salient characteristic of AD is episodic memory impairment. A few patients, however, present with focal cortical, non-memory symptoms, such as difficulties with language, visuospatial, or executive functions. These presentations are associated with specific patterns of atrophy and frequently...

Topics

Age of Onset
Alleles
Alzheimer Disease
Animals
Apolipoprotein E4
Humans

Source

Open in PubMed

Identifiers

PMID: 21185234
DOI: 10.1016/S1474-4422(10)70306-9

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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