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Article

Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele.

The Lancet. Neurology - 1 Mar 2011

van der Flier Wiesje M, Pijnenburg Yolande Al, Fox Nick C, Scheltens Philip

Abstract excerpt

Some patients with early-onset Alzheimer's disease (AD) present with a distinct phenotype. Typically, the first and most salient characteristic of AD is episodic memory impairment. A few patients, however, present with focal cortical, non-memory symptoms, such as difficulties with language, visuospatial, or executive functions. These presentations are associated with specific patterns of atrophy and frequently...

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Source

Identifiers

PMID: 21185234
DOI: 10.1016/S1474-4422(10)70306-9

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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