Article
Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome.
Cell - 19 Apr 1996
Musco G, Stier G, Joseph C, Castiglione Morelli M A, Nilges M, Gibson T J, Pastore A
Abstract excerpt
The KH module is a sequence motif found in a number of proteins that are known to be in close association with RNA. Experimental evidence suggests a direct involvement of KH in RNA binding. The human FMR1 protein, which has two KH domains, is associated with fragile X syndrome, the most common inherited cause of mental retardation. Here we present the three-dimensional solution structure of the KH module. The...
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