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Article

The elusive folding mechanism of KH1 domain of Fragile X messenger ribonucleoprotein 1.

Archives of biochemistry and biophysics - 1 Sept 2026

Troilo Francesca, Catalano Flavia, Comparini Eleonora, Pistoia Gianluca, Giardina Giorgio, Di Matteo Adele, Toto Angelo, Travaglini-Allocatelli Carlo

Abstract excerpt

K-homology (KH) domains are widespread RNA-binding modules characterized by a conserved fold despite low sequence identity. Among these, the KH domains of the Fragile X messenger ribonucleoprotein 1 (FMRP) play a key role in regulating mRNA translation in neurons, and their dysfunction, caused by missense mutations, is associated with Fragile X syndrome (FXS). In this work, by combining equilibrium and kinetic...

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PMID: 42324051
DOI: 10.1016/j.abb.2026.110909

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