Article
Richter's syndrome with different immunoglobulin light chain types. Molecular and cytogenetic features indicate a common clonal origin.
American journal of clinical pathology - 1 May 1992
Nakamine H, Masih A S, Sanger W G, Wickert R S, Mitchell D W, Armitage J O, Weisenburger D D
Abstract excerpt
To investigate the issue of clonality in Richter's syndrome, phenotypic, molecular genetic, and cytogenetic studies were performed on tumor tissue from a patient with concurrent chronic lymphocytic leukemia and diffuse large cell lymphoma in a single lymph node specimen. The tumor was biphenotypi...
Topics
- Aged
- Female
- Genotype
- Humans
- Immunoglobulin Light Chains
- Immunoglobulin kappa-Chains
- Immunoglobulin lambda-Chains
- Karyotyping
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphoma, Large B-Cell, Diffuse
- Molecular Biology