Article
Molecular immunoglobulin/T-cell receptor clonality diagnosis by gene scan in lymphoproliferative disorders.
Hematology (Amsterdam, Netherlands) - 1 Apr 2006
Shaheen Doaa, Elkader Amal Abd, Marouf Samy, Eltonbry Youssef, Elghaffar Hassan Abd
Abstract excerpt
There remains significant controversy over the techniques used for clonal diagnosis of lymphoproliferative disorders because of questions regarding the sensitivity, specificity and throughput. This has stimulated us to explore the use of gene scan to determine clonality of Immunoglobulin (Ig)/T-cell receptor (TCR) (gamma gene rearrangement in a variety of morphologically, cytochemically, pathologically and...
Topics
- Electrophoresis, Capillary
- Fluorescent Dyes
- Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
- Genes, T-Cell Receptor
- Genotype
- Humans
- Immunoglobulin Heavy Chains
- Immunophenotyping
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphoma, Non-Hodgkin
- Polymerase Chain Reaction