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Article

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells.

The Journal of biological chemistry - 25 Apr 2008

Waraich Rizwana Sanaullah, Weigert Cora, Kalbacher Hubert, Hennige Anita M, Lutz Stefan Z, Häring Hans-Ulrich, Schleicher Erwin D, Voelter Wolfgang, Lehmann Rainer

Abstract excerpt

The activation of the protein kinase C (PKC) family of serine/threonine kinases contributes to the modulation of insulin signaling, and the PKC-dependent phosphorylation of insulin receptor substrate (IRS)-1 has been implicated in the development of insulin resistance. Here we demonstrate Ser(357) of rat IRS-1 as a novel PKC-delta-dependent phosphorylation site in skeletal muscle cells upon stimulation with...

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PMID: 18285345
DOI: 10.1074/jbc.M708588200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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