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Article

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors.

Nature - 11 Apr 1996

Wan Y, Kurosaki T, Huang X Y

Abstract excerpt

The mitogen-activated protein kinase (MAPK) signalling cascade is a prominent cellular pathway used by many growth factors, hormones and neurotransmitters to regulate physiological responses. Although activation of the MAPK pathway by receptors with tyrosine kinase activity is well defined, the mechanism used by heterotrimeric G-protein-coupled receptors to activate this pathway is less clear. Here we show that...

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PMID: 8606776
DOI: 10.1038/380541a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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