Article
An analysis of the conformational changes that accompany the activation and inhibition of gelatinase A.
FEBS letters - 12 Feb 1996
Crabbe T, Kelly S M, Price N C
Abstract excerpt
The latent precursors of the matrix metalloproteinases (MMPs) are converted by (4-aminophenylmercuric)acetate to active forms that lose their propeptide as a result of autolysis. C.D. and an active site mutant of progelatinase A (MMP2) were used to demonstrate that, although propeptide removal is...
Topics
- Amino Acid Sequence
- Circular Dichroism
- Enzyme Activation
- Gelatinases
- Glycoproteins
- Humans
- Matrix Metalloproteinase 2
- Metalloendopeptidases
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Phenylmercuric Acetate
- Protease Inhibitors
- Protein Conformation
- Protein Precursors
- Tissue Inhibitor of Metalloproteinases