Article
An analysis of the conformational changes that accompany the activation and inhibition of gelatinase A.
FEBS letters - 12 Feb 1996
Crabbe T, Kelly S M, Price N C
Abstract excerpt
The latent precursors of the matrix metalloproteinases (MMPs) are converted by (4-aminophenylmercuric)acetate to active forms that lose their propeptide as a result of autolysis. C.D. and an active site mutant of progelatinase A (MMP2) were used to demonstrate that, although propeptide removal is accompanied by a decrease in the enzyme's beta-sheet content, the initial activation is achieved with only minor...
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