Article
Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.
The American journal of pathology - 1 Dec 1994
Emmert-Buck M R, Roth M J, Zhuang Z, Campo E, Rozhin J, Sloane B F, Liotta L A, Stetler-Stevenson W G
Abstract excerpt
Gelatinase A (MMP-2) and cathepsin B are proteinases which have been proposed to participate in human tumor invasion and metastasis. Precise quantitation of the activity of these enzymes in invading tumors has not been previously described. We utilized a novel tissue microdissection technique to determine levels of enzyme activity in specific microscopic areas of invasive human colon cancer. Tissue specimens...
Topics
- Base Sequence
- Cathepsin B
- Collagenases
- Colonic Neoplasms
- DNA
- Gelatinases
- Humans
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Metalloendopeptidases
- Molecular Sequence Data