Article
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
The Journal of biological chemistry - 18 May 2001
Brandstetter H, Grams F, Glitz D, Lang A, Huber R, Bode W, Krell H W, Engh R A
Abstract excerpt
The individual zinc endoproteinases of the tissue degrading matrix metalloproteinase (MMP) family share a common catalytic architecture but are differentiated with respect to substrate specificity, localization, and activation. Variation in domain structure and more subtle structural differences...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.