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Article

Interaction between the nucleotide exchange factor Mge1 and the mitochondrial Hsp70 Ssc1.

The Journal of biological chemistry - 16 Apr 1999

Sakuragi S, Liu Q, Craig E

Abstract excerpt

Function of Hsp70s such as DnaK of the Escherichia coli cytoplasm and Ssc1 of the mitochondrial matrix of Saccharomyces cerevisiae requires the nucleotide release factors, GrpE and Mge1, respectively. A loop, which protrudes from domain IA of the DnaK ATPase domain, is one of six sites of interaction revealed in the GrpE:DnaK co-crystal structure and has been implicated as a functionally important site in both...

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Identifiers

PMID: 10196216
DOI: 10.1074/jbc.274.16.11275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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