Article
p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia.
International journal of cancer - 20 Feb 1996
Ochiai A, Yamauchi Y, Hirohashi S
Abstract excerpt
In order to ascertain whether genetic alterations occur during the early stages of gastric carcinogenesis, abnormal accumulation of p53 protein and mutation of its gene in stomach tissue showing intestinal metaplasia were investigated using immunohistochemistry and polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. Immunohistochemistry detected 19 foci showing nuclear...
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