Article
Detection of p53 mutations in precancerous gastric tissue.
British journal of cancer - 6 Oct 2003
Morgan C, Jenkins G J S, Ashton T, Griffiths A P, Baxter J N, Parry E M, Parry J M
Abstract excerpt
Intestinal-type gastric cancer is preceded by gastritis and intestinal metaplasia. There is uncertainty regarding the stage at which genetic alterations in the p53 gene occur. Reactive oxygen species (ROS) may participate in the production of mutations and the inactivation of p53 is due to infection by the bacterium Helicobacter pylori. We have investigated whether alterations of the p53 gene can be detected in...
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