Article
p53 mutations and microsatellite instabilities in the subtype of intestinal metaplasia of the stomach.
Journal of Korean medical science - 1 Aug 2002
Kim Sung Soo, Bhang Choon Sang, Min Ki Ouk, Chae Hiun Suk, Choi Sang Wook, Lee Chang Don, Lim Keun Woo, Chung In Sik, Park Doo Ho
Abstract excerpt
To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI) both in the complete type (type I) and in the sulphomucin-secreting incomplete type (type III) intestinal metaplasia located adjacent to the gastric carcinoma. p53 mutations were observed in 13.3% of type I, in...
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