Article
Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc.
Genes & development - 15 Feb 1996
Desbarats L, Gaubatz S, Eilers M
Abstract excerpt
c-myc plans a key role in regulating mammalian cell proliferation and apoptosis. The gene codes for a transcription factor, Myc, that belongs to the helix-loop-helix/leucine zipper (HLH/LZ) family of proteins. Myc heterodimerizes with a partner protein termed Max; the heterodimeric complex binds to CAC(G/A)TG (E-box) sequences and activates transcription from these sites. However, several other HLH/LZ proteins,...
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