Article
Mutational analysis of Max: role of basic, helix-loop-helix/leucine zipper domains in DNA binding, dimerization and regulation of Myc-mediated transcriptional activation.
Oncogene - 1 Oct 1992
Reddy C D, Dasgupta P, Saikumar P, Dudek H, Rauscher F J, Reddy E P
Abstract excerpt
The Max protein forms a heterodimeric complex with the Myc family of proteins and binds to DNA in a sequence-specific manner. We investigated the role of the helix-loop-helix (HLH), leucine zipper (LZ) and basic domains of Max in protein complex formation, DNA-binding activity and transcriptional regulation. We mutagenized the basic, HLH and LZ domains of Max and studied the ability of the normal and mutant...
Topics
- Base Sequence
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Basic-Leucine Zipper Transcription Factors
- DNA
- DNA-Binding Proteins
- Humans
- Leucine Zippers
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins c-myc