Genetic patterning of the posterior neuropore region of curly tail mouse embryos: deficiency of Wnt5a expression.

Article

Genetic patterning of the posterior neuropore region of curly tail mouse embryos: deficiency of Wnt5a expression.

The International journal of developmental biology - 1 Jul 1998

Gofflot F, Hall M, Morriss-Kay G M

Abstract excerpt

The mouse mutant curly tail (ct) develops tail flexion defects and spina bifida as the result of delayed or failed closure of the posterior neuropore (PNP). With the aim of identifying genes involved in the chain of events resulting in defective neurulation, which can be detected at day 10.5 of d...

Topics

Animals
Embryonic and Fetal Development
Gene Expression Regulation, Developmental
Homeodomain Proteins
Mice
Mutation
Neural Tube Defects
Proto-Oncogene Proteins
Tail
Wnt Proteins
Wnt-5a Protein

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