Article
The complexity of selection at the major primate beta-defensin locus.
BMC evolutionary biology - 18 May 2005
Semple Colin A M, Maxwell Alison, Gautier Philippe, Kilanowski Fiona M, Eastwood Hayden, Barran Perdita E, Dorin Julia R
Abstract excerpt
BACKGROUND: We have examined the evolution of the genes at the major human beta-defensin locus and the orthologous loci in a range of other primates and mouse. For the first time these data allow us to examine selective episodes in the more recent evolutionary history of this locus as well as the ancient past. We have used a combination of maximum likelihood based tests and a maximum parsimony based sliding...
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