Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic Organization of the HumanPMS2Gene Family

1 Nov 1995

Abstract excerpt

The hPMS2 gene (HGMW-approved symbol PMS2) encodes a mutL homolog that causes hereditary non-polyposis colon cancer (HNPCC) when inherited in mutant form. We have here characterized the genomic structure of the hPMS2 gene to facilitate its analysis in HNPCC kindreds. The hPMS2 genomic locus was found to encompass 16 kb and consist of 15 exons. During its analysis, we identified a family of hPMS2-related genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8586419
DOI: 10.1006/geno.1995.9885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Organization of the HumanPMS2Gene FamilyPMID 8586419Read ↗

Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1.Semantic proximity Read ↗

Molecular genetics of hereditary non-polyposis colorectal cancer (HNPCC).Semantic proximity Read ↗

Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes <i>MSH2</i>, <i>MLH1</i>, <i>MSH6,</i> and <i>PMS2</i> responsible for hereditary nonpolyposis colorectal cancer (HNPCC)Semantic proximity Read ↗

Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.Semantic proximity Read ↗

MSH2 genomic deletions are a frequent cause of HNPCCSemantic proximity Read ↗

hMLH1 mutations in hereditary nonpolyposis colorectal cancer kindreds. Mutations in brief no. 182. Online.Semantic proximity Read ↗

Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes.Semantic proximity Read ↗

Molecular Analysis of Hereditary Nonpolyposis Colorectal Cancer in the United States: High Mutation Detection Rate among Clinically Selected Families and Characterization of an American Founder Genomic Deletion of the MSH2 GeneSemantic proximity Read ↗

A hPMS2 mutant cell line is defective in strand-specific mismatch repair.Semantic proximity Read ↗

Germline mutation analysis of hPMS2 gene in Chinese families with hereditary nonpolyposis colorectal cancer.Semantic proximity Read ↗

A 10‐Mb paracentric inversion of chromosome arm 2p inactivates <i>MSH2</i> and is responsible for hereditary nonpolyposis colorectal cancer in a North‐American kindredSemantic proximity Read ↗

Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.