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Clinical and field trials with attenuated Salmonella typhi as live oral vaccines and as "carrier" vaccines.

Research in microbiology - 1 Jan 2000

Levine M M, Hone D, Tacket C, Ferreccio C, Cryz S

Abstract excerpt

In recent years there has been a resurgence of research to develop new and improved attenuated strains of Salmonella typhi to function as live oral vaccines against typhoid fever and to serve as "carrier" vaccines to express foreign antigens of other pathogens and deliver them to the immune system. Strain Ty21a has served as a prototype in clinical and field trials to identify the optimal formulations and dosage...

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PMID: 2101470
DOI: 10.1016/0923-2508(90)90114-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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